Thesis (M.Sc.) -- University of Toronto, 1995.
|Series||Canadian theses = -- Thèses canadiennes|
|The Physical Object|
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In vivo 31P-MRS investigations have been widely used in small animals to study skeletal muscle function under normal and pathological conditions. Paradoxically in these studies, the benefit provided by 31P-MRS in terms of non-invasiveness is lost because of the utilization of experimental setups that integrate invasive devices for inducing muscle contractions and for measuring mechanical Cited by: In this chapter, techniques and application of multinuclear (1H, 13C, and 31P) in vivo magnetic resonance spectroscopy (MRS) for the assessment of skeletal muscle metabolism in health and disease are described. Studies focusing on glucose transport and utilization, lipid storage and consumption, handling of energy rich phosphates, and measurements of newly emerging noninvasive Author: Ladislav Valkovič, Radka Klepochová, Martin Krššák. Making muscle: skeletal myogenesis in vivo and in vitro developmental basis of skeletal muscle formation and function holds value for the elucidation and possible treatment of muscle pathologies. Notably, it is well known that rhabdomyosarcomas Determination front Dermomyotome Epiblast Nanog Fig. 1. The formation and differentiation of. The greatest merit of in vivo magnetic resonance spectroscopy (MRS) methodology used in biomedical research is its ability for noninvasively measuring a variety of metabolites inside a living organ. It, therefore, provides an invaluable tool for determining metabolites, chemical reaction rates and bioenergetics, as well as their dynamic changes.
MRS is maximized in the diagnosis of ear-ly DMD, when a very small amount of fat is not perceptible on standard imaging tech-niques. Numeric values objectively mea-sured by MRS directly reflect the amount of intramuscular fat in healthy subjects  Quantitative Skeletal Muscle MRI: Part 2, MR Spectroscopy and T2 Relaxation Time Mapping—. Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of (MRS) and showed that muscle bioenergetics, assessed as postexercise . insulin-resistant skeletal muscle and was not affected by exercise (Study V). In insulin-resistant human skeletal muscle, the effect of insulin tended to be larger following a single 2-h bout of exercise than in resting muscle ( % versus %, pmuscle of healthy individuals was –30 % (Study III). book of stress survival - Saturday, J MRS protocol for the in vivo determination of endogenous skeletal muscle metabolities. - Saturday, J PM; June morning. - Wednesday, July 8, AM; Rainbow Jellies - Saturday, J AM;.
Accurate and reliable quantification of brain metabolites measured in vivo using 1H magnetic resonance spectroscopy (MRS) is a topic of continued interest. of 31 P MRS in skeletal muscle. Purpose: Dynamic phosphorus magnetic resonance spectroscopy (31P MRS) during and after acute exercise enables the noninvasive in vivo determination of the mitochondrial capacity of skeletal muscle. The main purpose of this study was to evaluate non-invasively with magnetic resonance spectroscopy (1 H-MRS) changes in the concentrations of intracellular (IT) and extracellular (between muscle fibres) triglycerides (ET) in skeletal muscles of trained males (age range: 24–38 years) during two standard exercise protocols of alternating velocities. In vivo MRS. Both 1 H and 31 P have a high natural abundance and therefore in vivo MRS studies using these nuclei do not require isotopic enrichment. These techniques have become an .